I've never understood why "pathetic
is equal to "funny".

Spot the five differences.

uh...never mind...

Be obscure.

This was a study for a t shirt that was to have been done for an anti nuclear group in the NYC area. It was turned down because the group's leader didn't want to be associated with satire.

How to avoid getting a large following:  write and illustrate a joke that only microbiologists who read Larry Niven will understand.